Nous sommes heureux d'annoncer la publication dans Nature Medicine de l'algorithme EASO pour le traitement pharmacologique de l'obésité et de ses complications. Cet article, qui fait suite au nouveau cadre EASO pour le diagnostic, la stadification et la prise en charge de l'obésité chez l'adulte, s'aligne sur le concept de l'obésité en tant que maladie chronique liée à l'adiposité (ABCD).
EASO Medication Management Algorithm for Obesity: Personalising Obesity Medication Management
Obesity is a chronic, relapsing disease with far-reaching consequences for individual health and society. In addition to being a chronic disease in its own right, requiring sustained, personalised management and care, obesity is also a gateway to the many complications it drives, ranging from mechanical effects, such as joint disease and sleep apnoea, to metabolic and inflammatory conditions, including type 2 diabetes and cardiovascular diseases.
Effective obesity management must go beyond weight reduction alone; a holistic approach includes addressing complications, supporting mental well-being, improving physical function, and enhancing quality of life. Core strategies include behavioural modification, nutrition, physical activity, stress reduction, sleep improvement, and psychological support, alongside obesity management medications and, where appropriate, metabolic or bariatric procedures.
The number of approved obesity management medications is growing rapidly, offering clinicians more tools with distinct mechanisms of action. It is crucial that prescribing physicians understand the comparative effectiveness of these medications and how best to tailor treatment to individual patient needs. Because these medications differ in efficacy and in their impact on specific complications, personalised therapy is both feasible and necessary.
The new EASO medication management algorithm provides clinicians with practical guidance on aligning individual patient profiles with the evidence-based effects of available medications. Developed through rigorous analysis of randomised controlled trials and grounded in the new EASO obesity framework, the algorithm offers a simplified, clinically relevant tool to improve obesity management in adults.
As the publication reflects, data used here was available at the start of 2025. As the science continues to evolve, this algorithm will be updated.
Le Nature Medicine paper is available here: https://doi.org/10.1038/s41591-025-03765-w
Infographies
Please note that the algorithm infographics are based on data available as of 1 January 2025.
Download our Algorithm summary infographic
The revised deadline for inclusion of peer-reviewed publications in the 2026 edition of the EASO Framework for the Pharmacological Treatment of Obesity and Its Complications is November 21 2025.
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