{"id":130271,"date":"2026-03-02T08:33:56","date_gmt":"2026-03-02T08:33:56","guid":{"rendered":"https:\/\/easo.org\/?p=130271"},"modified":"2026-03-02T08:34:36","modified_gmt":"2026-03-02T08:34:36","slug":"easo-ecn-spotlight-meet-sandra-pinhancos","status":"publish","type":"post","link":"https:\/\/easo.org\/fr\/easo-ecn-spotlight-meet-sandra-pinhancos\/","title":{"rendered":"EASO ECN Spotlight : Sandra Pinhan\u00e7os"},"content":{"rendered":"<p><em>Je m'appelle Sandra Pinhan\u00e7os et je suis chercheuse postdoctorale au MIA-Portugal, Institut multidisciplinaire du vieillissement, CNC-UC, CiBB. J'\u00e9tudie le m\u00e9tabolisme et les th\u00e9rapies bas\u00e9es sur l'ARN, en particulier les microARN dans le dysfonctionnement des cellules \u03b2 et les maladies m\u00e9taboliques.<\/em><\/p>\n<p>Mon domaine d'expertise porte sur les troubles m\u00e9taboliques, en particulier le dysfonctionnement des cellules \u03b2 et les m\u00e9canismes de r\u00e9gulation m\u00e9di\u00e9s par les microARN qui prot\u00e8gent contre la glucolipotoxicit\u00e9 dans le diab\u00e8te et l'ob\u00e9sit\u00e9.<\/p>\n<p><strong>\u00c0 quoi ressemble une journ\u00e9e de travail type pour vous ?<\/strong><\/p>\n<p>Mes journ\u00e9es sont tr\u00e8s dynamiques et se ressemblent rarement. Certains jours sont consacr\u00e9s \u00e0 la r\u00e9daction, \u00e0 la pr\u00e9paration de demandes de subventions ou de manuscrits, tandis que d'autres sont pass\u00e9s au laboratoire o\u00f9 je con\u00e7ois et r\u00e9alise des exp\u00e9riences et o\u00f9 je g\u00e9n\u00e8re de nouvelles donn\u00e9es. Les r\u00e9unions constituent \u00e9galement une part importante de ma routine ; dans notre groupe, nous organisons r\u00e9guli\u00e8rement des discussions dans le cadre du Journal Club afin de nous informer sur les derni\u00e8res d\u00e9couvertes, de discuter des approches innovantes et d'inspirer de nouvelles orientations pour nos propres recherches.<\/p>\n<p><strong>Qu'est-ce qui a suscit\u00e9 votre int\u00e9r\u00eat pour le domaine de l'ob\u00e9sit\u00e9 ?<\/strong><\/p>\n<p>Mon premier int\u00e9r\u00eat pour l'ob\u00e9sit\u00e9 a \u00e9t\u00e9 suscit\u00e9 par la complexit\u00e9 de cette maladie. L'ob\u00e9sit\u00e9 n'est pas confin\u00e9e \u00e0 un seul organe mais affecte de multiples syst\u00e8mes, et son fardeau mondial croissant, ainsi que son lien \u00e9troit avec le diab\u00e8te de type 2, m'ont incit\u00e9 \u00e0 explorer certains m\u00e9canismes mol\u00e9culaires communs sous-jacents au dysfonctionnement m\u00e9tabolique. Je me suis particuli\u00e8rement int\u00e9ress\u00e9e \u00e0 la mani\u00e8re dont les microARN r\u00e9gulent les r\u00e9ponses des cellules \u03b2 au stress m\u00e9tabolique et \u00e0 la question de savoir s'ils peuvent am\u00e9liorer la r\u00e9silience cellulaire dans des conditions glucolipotoxiques. J'ai \u00e9t\u00e9 inspir\u00e9e par les travaux de Mirian Cnop sur le dysfonctionnement des cellules \u03b2. Cela m'a conduit \u00e0 int\u00e9grer l'expertise de notre laboratoire en biologie des microARN et en m\u00e9tabolisme pour identifier de nouveaux microARN th\u00e9rapeutiques capables de prot\u00e9ger les cellules \u03b2 de la mort induite par la glucolipotoxicit\u00e9.<\/p>\n<p><strong>Quel outil, m\u00e9thode ou astuce facilite votre vie professionnelle et que vous aimeriez que tout le monde connaisse ?<\/strong><\/p>\n<p>Ce qui me facilite grandement la vie au laboratoire, c'est le soutien et la bonne organisation de l'\u00e9quipe de direction de notre institut. Je partage \u00e9galement ma journ\u00e9e entre le travail de laboratoire et la r\u00e9daction, ce qui m'aide \u00e0 me concentrer sur une t\u00e2che \u00e0 la fois et \u00e0 rester efficace. Nous organisons fr\u00e9quemment des s\u00e9ances de brainstorming, ce qui nous permet de g\u00e9n\u00e9rer de nouvelles id\u00e9es, de r\u00e9soudre des probl\u00e8mes en collaboration et de rendre nos discussions scientifiques plus productives.<\/p>\n<p><strong>En quoi le fait de faire partie de l'ECN a-t-il chang\u00e9 votre parcours jusqu'\u00e0 pr\u00e9sent ?<\/strong><\/p>\n<p>Faire partie de l'ECN et participer \u00e0 la <a href=\"https:\/\/easo.org\/fr\/easo-early-career-network\/ecn-masterclass\/\">Masterclass ECN<\/a> m'a permis de rencontrer des pairs \u00e0 diff\u00e9rents stades de leur carri\u00e8re et d'horizons divers, me rappelant que je fais partie d'un r\u00e9seau de soutien de chercheurs interdisciplinaires engag\u00e9s dans l'avancement de la science m\u00e9tabolique. De plus, les webinaires du eLearning Hub ont \u00e9t\u00e9 d'une valeur inestimable pour me tenir au courant des derni\u00e8res recherches, des nouvelles m\u00e9thodes et des strat\u00e9gies innovantes dans le domaine.<\/p>\n<p><strong>Quel a \u00e9t\u00e9 le projet le plus gratifiant ou le plus passionnant sur lequel vous ayez travaill\u00e9 ?<\/strong><\/p>\n<p>Le projet le plus gratifiant sur lequel j'ai travaill\u00e9 ces derni\u00e8res ann\u00e9es consistait \u00e0 utiliser une strat\u00e9gie de criblage non biais\u00e9e pour identifier les microARN capables de prot\u00e9ger les cellules \u03b2 de la glucolipotoxicit\u00e9. Gr\u00e2ce \u00e0 cette approche, nous avons identifi\u00e9 le miR-642a-3p comme \u00e9tant \u00e0 la fois un biomarqueur prometteur et un candidat th\u00e9rapeutique potentiel pour pr\u00e9server la fonction des cellules \u03b2. Ce projet \u00e9tait particuli\u00e8rement significatif car j'ai rejoint le laboratoire nouvellement \u00e9tabli du Dr Hugo Fernandes et j'ai aid\u00e9 \u00e0 lancer une nouvelle ligne de recherche ax\u00e9e sur les microARN dans les maladies m\u00e9taboliques. Il \u00e9tait passionnant de contribuer non seulement \u00e0 la conception exp\u00e9rimentale et \u00e0 la production de donn\u00e9es, mais aussi \u00e0 la d\u00e9finition de l'orientation de la recherche du laboratoire. Au-del\u00e0 de la d\u00e9couverte scientifique, ce travail a d'importantes implications translationnelles, car il ouvre de nouvelles voies pour d\u00e9velopper des strat\u00e9gies bas\u00e9es sur les microARN afin de prot\u00e9ger les cellules \u03b2 dans le diab\u00e8te et l'ob\u00e9sit\u00e9.<\/p>\n<p><strong>Quel conseil donneriez-vous \u00e0 celui ou celle qui d\u00e9bute aujourd'hui ?<\/strong><\/p>\n<p>Je dirais \u00e0 ma cadette de rester r\u00e9siliente, d'appr\u00e9cier le processus dans le laboratoire et de s'amuser en cours de route, tout en d\u00e9veloppant des comp\u00e9tences en laboratoire et en informatique, y compris en bio-informatique, afin d'\u00e9largir l'impact de ma recherche.<\/p>\n<p><strong>Qu'est-ce qui vous enthousiasme le plus dans l'avenir de la recherche sur l'ob\u00e9sit\u00e9 ?<\/strong><\/p>\n<p>Ce qui m'enthousiasme le plus dans l'avenir de la recherche sur l'ob\u00e9sit\u00e9, c'est la possibilit\u00e9 de d\u00e9velopper des syst\u00e8mes d'administration cibl\u00e9s pour les microARN, permettant une modulation pr\u00e9cise de la fonction des cellules \u03b2 du pancr\u00e9as. Je suis particuli\u00e8rement motiv\u00e9e par la possibilit\u00e9 de cr\u00e9er des th\u00e9rapies bas\u00e9es sur les microARN qui pourraient traiter efficacement l'ob\u00e9sit\u00e9 et les complications m\u00e9taboliques qui y sont associ\u00e9es. Je suis \u00e9galement fascin\u00e9 par la fa\u00e7on dont des interventions telles que la chirurgie bariatrique peuvent remodeler les profils de miARN, ce qui pourrait conduire \u00e0 l'identification de nouveaux biomarqueurs et \u00e0 la compr\u00e9hension des m\u00e9canismes \u00e0 l'origine des am\u00e9liorations m\u00e9taboliques.<\/p>\n<p><strong>O\u00f9 vous voyez-vous dans cinq ans ? Quel est votre projet ou poste de r\u00eave ?<\/strong><\/p>\n<p>Dans cinq ans, je souhaite contribuer \u00e0 l'interface entre la biologie des maladies m\u00e9taboliques et la d\u00e9livrance d'ARN, en me concentrant sur le d\u00e9veloppement de strat\u00e9gies bas\u00e9es sur les miARN pour pr\u00e9server la fonction des cellules \u03b2 du pancr\u00e9as dans l'ob\u00e9sit\u00e9 et le diab\u00e8te. Parall\u00e8lement, j'esp\u00e8re continuer \u00e0 encadrer de jeunes chercheurs et attirer des \u00e9tudiants en doctorat tr\u00e8s motiv\u00e9s afin de contribuer \u00e0 la mise en place d'un environnement de recherche collaboratif et innovant.<\/p>\n<p><strong>Quels types de projets ou d'initiatives vous int\u00e9resseraient le plus dans le cadre d'une collaboration avec d'autres membres du RCE ?<\/strong><\/p>\n<p>Au sein de l'ECN, je suis particuli\u00e8rement int\u00e9ress\u00e9e par les projets de collaboration qui int\u00e8grent diverses perspectives multidisciplinaires sur l'ob\u00e9sit\u00e9, en combinant la recherche mol\u00e9culaire, les connaissances cliniques et les approches informatiques. Je suis enthousiaste \u00e0 l'id\u00e9e de travailler avec d'autres membres pour concevoir des \u00e9tudes innovantes, partager mon expertise et d\u00e9velopper des solutions qui pourraient d\u00e9boucher sur de nouvelles strat\u00e9gies th\u00e9rapeutiques.<\/p>\n<p>Connectez-vous avec Sandra !<\/p>\n<p>Courriel : <a href=\"mailto:sandra.pinhancos@uc.pt\">sandra.pinhancos@uc.pt<\/a><\/p>\n<p>LinkedIn : <a href=\"https:\/\/www.linkedin.com\/in\/sandra-mimoso-pinhan%C3%A7os-073542149\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.linkedin.com\/in\/sandra-mimoso-pinhan%C3%A7os-073542149\/<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>My name is Sandra Pinhan\u00e7os, and I am a Postdoctoral Researcher at MIA-Portugal, Multidisciplinary Institute of Ageing, CNC-UC, CiBB. I investigate metabolism and RNA-based therapies, specifically microRNAs in \u03b2-cell dysfunction and metabolic disease. My area of expertise focuses on metabolic disorders, particularly \u03b2-cell dysfunction and microRNA-mediated regulatory mechanisms that protect against glucolipotoxicity in diabetes and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":130257,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[15,522,538],"tags":[],"class_list":["post-130271","post","type-post","status-publish","has-post-thumbnail","hentry","category-early-career-network","category-ecn","category-ecn-spotlight"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>EASO ECN Spotlight: Meet Sandra Pinhan\u00e7os - EASO<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/easo.org\/fr\/easo-ecn-spotlight-meet-sandra-pinhancos\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EASO ECN Spotlight: Meet Sandra Pinhan\u00e7os - EASO\" \/>\n<meta property=\"og:description\" content=\"My name is Sandra Pinhan\u00e7os, and I am a Postdoctoral Researcher at MIA-Portugal, Multidisciplinary Institute of Ageing, CNC-UC, CiBB. 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